Sally Letter Adebamowo, Donna Spiegelman, Walter C Willett, Kathryn Yards Rexrode, Connection between consumption from magnesium, potassium, and calcium and you may danger of heart attack: dos cohorts folks girls and upgraded meta-analyses, The fresh new American Record away from Logical Diet, Frequency 101, Procedure six, , Profiles 1269–1277,
Abstract
Background: Prospective studies towards family regarding magnesium, potassium, and you may calcium supplements intakes that have heart attack chance try contradictory, and the degree, the outcome out-of a mixed nutrient eating plan get hasn’t been checked-out.
Objective: We tested contacts ranging from intakes regarding magnesium, potassium, and you may calcium and you will risk of experience coronary attack in the 86,149 feamales in the fresh new Nurses’ Wellness Data (NHS) I and you may 94,715 feamales in brand new NHS II.
Design: In this prospective cohort analysis, i determined Hrs out of coronary attack from the quintiles from intake per nutrient and for a mixed diet plan score of the many step three vitamins that with multivariate Cox proportional risk habits. Additionally, we current meta-analyses on the weight-loss consumption of those minerals and you can danger of coronary arrest.
Results: While in the go after-upwards (29 y on NHS I; twenty-two y on NHS II) all in all, 3780 incident coronary attack circumstances was recorded. Pooled multivariate RRs away from total coronary attack for women in the higher compared to a reduced quintiles were 0.87 (95% CI: 0.78, 0.97) getting full magnesium, 0.89 (95% CI: 0.80, 0.99) getting total potassium, and you may 0.97 (95% CI: 0.87, 1.09) having overall calcium intake. Pooled RRs for ladies regarding higher weighed against a reduced quintiles away from a combined nutrient diet plan score was basically 0.72 (95% CI: 0.65, 0.81) to have complete stroke, 0.78 (95% CI: 0.66, 0.92) to own ischemic heart attack, and you may 0.80 (95% CI: 0.61, step 1.04) to possess hemorrhagic coronary arrest. On the updated meta-analyses of all possible degree up until now, new shared RR out of complete heart attack try 0.87 (95% CI: 0.83, 0.92) having a 100-mg/d escalation in magnesium intake, 0.91 (95% CI: 0.88, 0.94) getting a 1000-mg/d upsurge in potassium intake, and you will 0.98 (95% CI: 0.94, step one.02) having a 300-mg/d escalation in calcium supplements consumption.
Conclusions: A blended mineral diet plan rating is inversely of the danger of coronary attack. Highest intakes out-of magnesium and potassium yet not calcium supplements was in fact plus somewhat of the reduced danger https://datingranking.net/political-dating/ of stroke in women.
Inclusion
Magnesium is an essential mineral and you will cofactor to own >300 enzymatic responses in the torso ( 1). Magnesium is the second really-abundant intracellular cation near to potassium ( 2). Calcium supplements is one of-plentiful nutrient in the human body. For example magnesium and you can potassium, calcium are significantly in cardio attributes ( 3). Large slimming down consumption of each of these nutrition were claimed so you can lower danger of blood pressure levels ( 4– 7), which is the prominent modifiable coronary arrest chance factor. However, never assume all prospective education checked the latest family ranging from weight loss and you will supplemental consumption ones nutrition and you can likelihood of heart attack in females, and you can performance was basically inconsistent. Prospective studies for the Europe shown magnesium consumption, but not consumption from potassium or calcium, are rather in the less threat of coronary attack ( seven, 8). In the united states, consumption out of potassium and magnesium, however off calcium supplements, had been associated with reduced coronary attack risk into the males ( 9), whereas calcium supplements and you will potassium consumption, yet not magnesium intake, was associated with quicker stroke exposure in women ( 10). And, that data displayed no full relationship anywhere between any of these nutritional elements and risk of heart attack ( 11).
The few possible observational education which were presented don’t include follow-upwards beyond 15 y along with a somewhat small number of experience coronary attack events, along with very degree, the separate aftereffect of for every single mineral intake of pills and you will coronary attack types wasn’t tested. On this page, you can expect facts with the association of every nutrient consumption out of dieting and pills with risk of full, ischemic, and hemorrhagic experience strokes. While doing so, i hypothesized one a mixed diet rating of all step three nutrients can be of this less coronary attack exposure mainly because nutritional elements exist with her inside delicacies, and you can consumption try firmly coordinated. We treated these seeks when you look at the You ladies who was followed prospectively in the 2 large cohorts the newest Nurses’ Health Investigation (NHS) 5 We and II.
