Two hundred and you may eighty-six cases of NF1 and you can female breast cancer have been understood

One of several 58 training within the detailed study, 41 was indeed instance accounts, you to definitely try a case series, thirteen was retrospective cohort education, two have been possible cohort education, and another try a mix-sectional cohort investigation. The feminine NF1 people with cancer of the breast came from 23 some other regions, on the most of her or him via the usa regarding The usa (38%), Uk (31%), and you will Japan (12%). Functions of them cases is actually explained when you look at the Desk step 1.

Breast cancer stage at time of diagnosis was reported in 54 cases (27 cases of patients < 50 years of age and 27 cases of patients ?50 years of age)

Of the 286 cases identified, 181 reported the age of the patient. Mean age at breast cancer diagnosis was 49.3 years with a median age of 46 years and an interquartile range of 38.3 to 58.0 years. The majority of the patients were < 50 years of age with 53% < 50 years old, 28% between 35 and 44 years old and 15% < 35 years old. Age distribution of the incidence of breast cancer identified in these NF1 cases was evaluated based on their age at the time of diagnosis and revealed a peak age of diagnosis between the ages of 34 to 44 years. 2a).

Detailed study off breast cancer instances reported. a Age delivery of your chance regarding breast cancer known in 181 NF1 people compared to SEER databases stated cancer of the breast decades shipping out-of incident instances. b Shipping away from breast cancer stage on duration of analysis out-of cancer of the breast identified from inside the 54 NF1 people. c Years shipping of the occurrence out-of cancer of the breast death identified in 76 NF1 clients than the SEER database claimed nipple malignant tumors many years shipments off deaths

So it occurrence out-of cancer of the breast cases is than the SEER database to own claimed cancer of the breast ages distribution regarding incident instances, which displayed a highest age prognosis within chronilogical age of 55 to help you https://datingranking.net/nl/japan-cupid-overzicht/ 64 ages in the standard inhabitants (Fig

The type of breast cancer was reported in 110 cases; invasive ductal carcinoma (IDC) was the most commonly reported breast cancer subtype (75.5%). The other 176 breast cancer cases were identified as breast carcinoma. When analyzing all the female NF1 patients with breast cancer, the majority presented with stage I or II disease. However, when separated by age, women < 50 years of age presented with more advanced disease compared to those ?50 years of age (56% vs. 22% stage III-IV, respectively, p = 0.005; Fig. 2b).

Follow-up information was provided in 76 of the reported cases. Mean follow-up time was 44.7 months with a range of 1.9 to 204 months. Nearly half of the reported patients were dead at the time of last follow-up. Mean age at breast cancer death was 45.7 years with a median age of 48.5 years and an interquartile range of 41.3–59.7 years. The majority of the patients were < 50 years of age at time of breast cancer death with 64% < 50 years old, 38% between 35 and 44 years old and 10% < 35 years old. This incidence of breast cancer deaths was compared to the SEER database for reported breast cancer age distribution of deaths, demonstrating a peak age of death between the ages of 55 to 64 years in the general population (Fig. 2c). The relative survival of the female NF1 patients with breast cancer identified in this study was compared to the general population using the SEER database controlling for age and year at diagnosis for each patient (Fig. 3). The median survival for this entire NF1 breast cancer cohort was 5 years compared to the reported median breast cancer survival of over 20 years in the general population using the SEER database. When separated by age, the median survival of the female NF1 patients with breast cancer identified in this study was 5.58 years in those < 50 years of age and over 15 years in those ?50 years of age.