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Review out-of RBC Folate, Serum Folate, and you will Nutritional Ba dozen
Baseline Services
The demographic characteristics and nutrient levels of the study population are summarized in Table 1. The mean (± SD) age and preconceptional BMI of the pregnant women were (± 3.97) years and (± 2.81) kg/m 2 , respectively. Among the pregnant women, %, %, and %, respectively, had a family history of diabetes, smoking exposure, and alcohol consumption during gestation. FAS was found in % (674 out of 1,058) of the pregnant women, of whom % (650 out of 674) took compound vitamin supplements. The median (interquartile range) concentrations of RBC folate, serum folate, and vitamin B12 were (–), (–), and (–) (Supplementary Fig. 1).
Persisted details try shown since form ± SD or average (interquartile diversity), and you will categorical details try indexed as the n (%). Zero lost studies lived in the modern research.
Among 1,058 pregnancies, GDM occurred in 180 women (%) with a mean follow-up time of 11.1 ± 1.5 gestational weekspared with the group without GDM, median RBC folate and vitamin B12 levels in early pregnancy were significantly higher in the group with GDM (for RBC folate: vs. ng/mL, P = 0.045; for vitamin B12: vs. pg/mL, P = 0.002). No significant differences in serum folate concentration between GDM and non-GDM were found (Supplementary Fig. 2).
Relationships out-of Maternal Folate Condition and you will Nutritional B12 That have GDM Chance
FAS was associated with an increased risk of GDM (adjusted OR [aOR] 1.73 [95% CI 1.19–2.53]; P = 0.004). No significant association was found between RBC folate and serum folate levels as continuous variables with GDM (for RBC folate: aOR 1.07 [95% CI 0.99–1.15]; P = 0.08; for serum folate: aOR 1.01 [95% CI 0.97–1.05]; P = 0.43) (Table 2)pared with pregnant women who had RBC folate levels <400 ng/mL, those with RBC folate ?600 ng/mL were associated with ?1.60-fold higher odds of GDM (aOR 1.58 [95% CI 1.03–2.41]; P = 0.033). An obvious increased risk development across RBC folate groups with GDM risk was observed (Ptrend = 0.021) Korean dating site.
Vitamin B12 level was significantly associated with GDM risk (OR 1.14 per 100 pg/mL [95% CI 1.04–1.24]; P = 0.002). Of note, pregnant women in the upper tertile of vitamin B12 had approximately twofold higher odds of GDM (aOR 2.00 [95% CI 1.35–2.96]; P = 0.001). We also investigated the nonlinear relationship among RBC folate, vitamin B12, and GDM risk. The RCS regression model revealed that higher levels of RBC folate and vitamin B12 were associated with an increased risk of GDM in a nonlinear fashion (Fig. 1).
RCS regression analysis of RBC folate and vitamin B12 with GDM risk. A: RBC folate 400 ng/mL was selected as the reference level. B: The median of vitamin B12 298 pg/mL was selected as the reference level. The lines indicate estimated ORs, and the light blue areas represent 95% CI.
RCS regression analysis of RBC folate and vitamin B12 with GDM risk. A: RBC folate 400 ng/mL was selected as the reference level. B: The median of vitamin B12 298 pg/mL was selected as the reference level. The lines indicate estimated ORs, and the light blue areas represent 95% CI.
Moreover, RBC folate concentration in early pregnancy was positively correlated with OGTT 1-h and 2-h serum glucose levels, with the correlation coefficient r values being 0.19 and 0.11, respectively (both P < 0.001). Similar correlations were observed between vitamin B12 and 1-h and 2-h serum glucose level (both r values were 0.13; P < 0.001).
Connections away from Folate/Vitamin B12 Harmony Having GDM Exposure
A greater serum folate/vitamin B12 ratio was associated with a decreased GDM risk (aOR 0.98 [95% CI 0.97–0.99]; P = 0.009) (Supplementary Table 1). The risk of GDM became significantly lower in the Q3 tertile compared with that in the Q1 tertile (aOR 0.60 [95% CI 0.41–0.98]; P = 0.042) and showed a significant trend (Ptrend = 0.041). However, no significant association was found between RBC folate/vitamin B12 ratio and GDM. When analyzed as percentile ratios, neither RBC folate/vitamin B12 nor serum folate/vitamin B12 was significantly associated with GDM (Table 3).